The human body continually attempts to eliminate toxins through the liver. Thus, physicians are challenged to identify their patient's exposure to toxicants, and support the body with the appropriate nutrients/nutriceuticals. But how can a physician confirm that the intervention is indeed improving their patient's ability to detoxify?

The urine Hepatic Detox Profile from Doctor's Data might assist as it was created to easily detect exposure to toxicants while also determining detoxification capacity.

 
  •  Assessment of status phase I and phase II detoxification
  •  Assessment of chemical exposure and impaired liver function
  •  No hepatotoxic challenge drugs required
  •  Simple first morning void urine collection
  •  Low prompt payment price of $116

 
Exposure

A reliable biomarker for exposure to toxic chemicals is urinary D-gluaric acid. Elevated levels of D-glucaric acid indicates induction of cytochrome P-450 enzymes (phase I) as a result of exposure to many xenobiotics (e.g. pesticides, fungicides, petrochemicals, drugs, toluene, formaldehyde, sytrenes, etc.) Such exposures induce the glucuronic acid enzymatic pathway and production of D-glucaric acid, thus urinary D-glucaric acid is an indirect byproduct of chemical exposure and phase I detoxification induction.

Detoxification Capacity

The urinary level of mercapturic acids indicates the quantitatively the degree of activity, or capability of phase II detoxification. Mercapturic acids are the final excretory products of detoxification and include a variety of functionalized xenobiotics that have been conjugated with glutathione or L-cysteine prior to excretion. Low levels of mercapturic acids are consistent with insufficient levels of glutathione and/or cysteine. When the rate of formation of functionalized xenobiotics (phase I) exceeds the capacity of phase II detoxificaiton, more potent toxins accumulate.
   click image for web version of sample report
 
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Urine Porphyrins Profile

 
Urinary Porphyrins are oxidized intermediate metabolites of heme biosynthesis and have been associated with genetic disorders, metabolic disturbances/disease, poor nutritional status and oxidative stress. Additionally, specific urine porphyrin profiles are associated with high level mercury, arsenic, lead and some chemicals and drugs. Precoproporphyrins, associated with mercury, are reported separately and per unit of uroporphyrin to increase detection even when heme biosynthesis is low. This non-invasive test requires a single first morning void or 24 hour urine collection.


Follow links below to view sample reports of other suggested Doctor's Data profiles
 
   click image for web version of sample report
 
 
Want to see the latest research on this topic?
 

Eckert E1, Leng G, Gries W, Göen T.  Excretion of mercapturic acids in human urine after occupational exposure to 2-chloroprene.  Arch Toxicol. 2013 Jun;87(6):1095-102. 

Morimoto et al.   Significance of urinary glucaric acid measurement and its application to paclitaxel therapy.   Gan To Kagaku Ryoho. 2009 Nov;36(11):1857-61

Zarth AT, Carmella SG, Le CT, Hecht SS.  Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide.  J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:126-31.
 
 
Why choose Doctor's Data, Inc.?
 
Doctor's Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced CLIA-licensed laboratory since 1972.

A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, cardiovascular risk, liver and metabolic abnormalities, and more
.