Earn up to 14.5
Laboratory, Endocrine, & Neurotransmitter Symposium
February 7-9, 2020
Las Vegas, NV
Gain additional clinical insight and treatment considerations to evaluate some of the most prevalent and challenging conditions that patients present with, including depression, anxiety, altered mental focus and stamina, sexual dysfunction, sleep disturbances, addictions and dependencies, weight management, and chronic disease. Register today!
Neuroendocrine Testing and Patient Support: Frequently Asked Questions
By: Heather Hydzik ND
December 4th, 2019
Join our clinical staff and special guests on the first Wednesday of every month at 9:30 AM and 12:00 PM PST. This free, live webinar series will cover a variety of neuroendocrine topics that will enhance your knowledge, with clinically applicable testing and treatment considerations. 1 CE credit available from the OBNM.
November 16-17, 2019
We will be in Portland on November 16-17 at the OANP conference. Stop by our booth and learn more about our testing services.
Las Vegas, NV:
December 13-15, 2019
We will be in fabulous Las Vegas next month for the A4M conference. Learn about the new GI360TM profile and how our testing can help your practice.
Microbiota-Gut-Brain Axis: Behavior and Dementia Implications
By Julia Malkowski, ND, DC | November 12, 2019
It is common knowledge that the gut microbiome influences neurologic conditions via the microbiota-gut-brain axis. The microbiota-gut-brain axis has also been implicated in behavior. Behavior in adolescence has proven predictive of dementia development decades later in life. Understanding the underlying mechanisms of the microbiota-gut-brain axis via microbiome profiling and metabolism could lead to novel approaches for preventing dementia decades before symptoms appear.
A diverse gut microbiome has been associated with behaviors related to positive mood, curiosity, sociability, and impulsivity according to researchers studying toddler behavior and their microbiome. Extroverted behavior in boys was associated with bacteria of the Parabacteroides, Rikenellaceae, Ruminococcaceae families and Dialister genera, while girls with an abundance of Rikenellaceae displayed more fear behaviors than girls with a diverse microbiome. A less diverse microbiome was associated with behaviors such as self-restraint, cuddliness, and focused attention in girls. The researchers noted that a child’s temperament, or how they handle stress, was influenced by their gut microbiome, especially for boys.
There is a link between anti-social behaviors and a gastrointestinal environment enriched with Clostridiales spp in an animal model. Behaviors associated with depression, such as social avoidance and despair-like behaviors, were prevented by the administration of a broad-spectrum antibiotic cocktail. The behaviors of social avoidance and despair were transferred to germ free mice, after a fecal transplant consisting of Clostridiales, Lachnospiraceae and Ruminococcaceae spp. Researchers also noted a disruption in gut biosynthesis of tryptophan, tyrosine, and phenylanine in recipient mice with behavioral changes. The underlying mechanism of action linking the microbiota-gut-brain axis and behavior may lie in key bacterial metabolites effecting gene expression in the prefrontal cortex and gut derived amino acids.
New research linking childhood behavior to the development of dementia later in life suggests the microbiota-gut-brain axis might influence cognition decades before symptoms appear. Researchers found that vigor, calm, and maturity behaviors in adolescence were associated with lower risk of dementia 54 years later. We now know that behavior is influenced by the microbiota, and it has been established that the development of dementia is linked to the microbiota. Although we do not have data in this study on the adolescents’ microbiota in relation to the development of dementia, future studies should include microbiome profiling and metabolism due to a potential link. Future studies to identify bacterial metabolites of the microbiota-gut-brain axis could direct novel preventative treatment options for neurocognitive disorders. Psychobiotics, bacteria administered for mental health benefit, may be utilized prophylactically and as potential adjunctive treatment.
While the microbiota-gut-brain axis has been implicated in neurological conditions, it is also at play influencing quotidian behavior. The proposed mechanism of action lies in bacterial metabolites which influence the pre-frontal cortex and gut derived amino acids. Adolescent behavior has proven predictive of dementia development decades later, therefore a potential link exists between the adolescent microbiota and dementia pathogenesis. In light of this new evidence, further research into microbiome profiling and metabolism in relation to neurocognitive disorders is warranted. Clinicians can rest assured addressing the microbiota will benefit their patients, not only in the immediate future, but potentially decades down the line as well.
Alkasir, R., Li, J., Li, X. et al. Protein Cell (2017) 8: 90. https://doi.org/10.1007/s13238-016-0338-6
Chapman BP, Huang A, Peters K, et al. Association Between High School Personality Phenotype and Dementia 54 Years Later in Results From a National US Sample. JAMA Psychiatry. Published online October 16, 2019. doi:10.1001/jamapsychiatry.2019.3120
Gacias M, Gaspari S, Santos PM, et al. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. Elife. 2016;5:e13442. Published 2016 Apr 20. doi:10.7554/eLife.13442
Pedersen, Traci. Gut Bacteria Impacts Toddlers’ Behavior, Particularly Boys. Psych Central. 8 Aug 1018.
Vuong HE, Yano JM, Fung TC, Hsiao EY. The Microbiome and Host Behavior. Annu Rev Neurosci. 2017;40:21–49. doi:10.1146/annurev-neuro-072116-031347
Introducing the new GI360™ Profile from Doctor's Data, offering extensive assessment of the gastrointestinal microbiome
GI360™ is a powerful tool to profile the microbiome and compare results to a published normobiotic reference population. Identify gut pathogens to aid in diagnosis and guide selection of treatment. Identify risk profiles for major diseases and chronic conditions
The GI360™ Profile includes:
- PCR Analysis for the Abundance and Diversity of Key Bacterial Populations of the GI Microbiome
- PCR Detection of Pathogenic Bacteria, Viruses and Parasites
- Comprehensive Parasitology by Microscopy
- MALDI-TOF ID of Cultured Bacteria and Yeast
- Broad Range of Stool Chemistry Markers
- Standardized Susceptibility Testing of Isolated Bacteria and Yeast