Doctor’s Data Inc. (DDI) is pleased to announce the launch of our new DNA Methylation Pathway Profile.  The DNA Methylation Pathway Profile allows clinicians to screen their patients for a variety of single nucleotide polymorphisms, or SNPs that may impact the function of important biochemical processes such as methionine metabolism detoxification, hormone balance and Vitamin D function.

  

Doctor’s Data provides interpretive paragraphs that accompany all final reports and clinicians have access to live scientific support.
 
Why would doctors screen patients for SNPs?   

Identifying SNPs that influence health and disease risk allows clinicians to support their patients with appropriate nutritional support and lifestyle changes to maximize health and wellness. 
 
What genes are screened for SNPs on the new DDI DNA Methylation Pathway Profile?

ACAT
- acetyl coenzyme A acetyltransferase
plays an important role beta-oxidation of fatty acids and protein metabolism and completes ketone metabolism, synthesizing acetyl-Co-A for energy production.
AHCY – adenosylhomocysteinase converts S-adenosylhomocysteine (SAH) to homocysteine
BHMT - betaine-homocysteine methylatransferase catalyzes the transfer of a methyl group from betaine to homocysteine to produce methionine and dimethylglycine (DMG)
CBS – cystathionine beta-synthase catalyzes the vitamin B6–dependent reaction between serine and homocysteine, producing cystathionine en route to cysteine, taurine and glutathione.
COMT - catechol-O-methyltransferase activity facilitates neurotransmitter balance and deactivation of hydroxy estradiols
MAO A - monoamine oxidase type A detoxifies biological and xenobiotic amines; degrades neurotransmitters such as serotonin and dopamine, and the catecholamines epinephrine and norepinephrine in both the central and peripheral nervous systems. 
MTHFR – methylenetetrahydrofolate reductase helps pull homocysteine into the methionine synthesis cycle which facilitates maintenance of normal levels of homocysteine, methionine, and SAMe.
MTR – methionine synthase catalyzes the re-methylation of homocystiene to methionine utilizing methylcobalamin (methyl B-12) as a cofactor
MTRR – methionine synthase reductase  regenerates methionine synthase (MTR) via a methylation reaction that uses S-adenosylmethionine (SAM) as a donor
NOS – E
ndothelial nitric oxide synthase synthesizes nitric oxide (NO) from arginine
SHMT – serine hydroxymethyltransferase catalyzes the interconversion of glycine and serine
SUOX – sulfite oxidase oxidizes sulfite to sulfate, a required step in the elimination of sulfite and production of important sulfate anions
VDR - vitamin D receptor binds 1,25-dihydroxy vitamin D to form a functional signaling molecule that may influence up to a third of the human genome
 

Why choose Doctor’s Data Inc. for SNP Analysis?

Doctor’s Data Inc. (DDI) provides interpretive paragraphs that accompany all final reports and clinicians have access to live scientific support.   Additionally, DDI has over 40 years’ of experience providing specialty testing to healthcare practitioners around the world.  DDI is a licensed CLIA laboratory with appropriate state certifications and participates in numerous quality assurance/proficiency testing programs including the College of American Pathology, New York State DOH and Le Centre de Toxicologie du Quebec.

 
How does the new DNA Methylation Pathway Profile relate to other available DDI tests?

DDI’s
Plasma Methylation Profile provides a direct assessment of several major metabolites that may evaluate methionine metabolism and function in the presence or absence of influential SNPs. The Plasma Methylation Profile is a great follow-up test if SNPs affecting detoxification or methionine metabolism are identified by the DNA Methylation Pathway Profile.

DNA methylation patterns may change with increased oxidative stress.  SNP-associated changes in gene expression may result in excessive oxidative stress.  The DNA Oxidative Damage Profile provides a quantitative assessment of ongoing oxidative damage or stress to the body, and may be used to monitor the effects of comprehensive detoxification and antioxidant therapies

Methionine metabolism and phase II detoxification processes may be influenced by SNPs such as MTHFR, MTR, MTRR, SHMT, etc.  The Hepatic Detox Profile provides a functional assessment of phase I and phase II liver detoxification activities, and may provide important information regarding the phenotypic expression of SNPs associated with detoxification processes.

VDR (the vitamin D receptor) SNPs decrease receptor efficiency, which may result in "sluggish" detoxification processes. An inefficient receptor requires a sufficiency of substrate. Vitamin D levels may be monitored with DDI's Vitamin D (25OH D2 & D3) test.