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Urinary 8-OHdG Analysis: The Outcomes Could Be Damaging

 

Reactive oxygen species (ROS) may be produced as a result of normal oxygen metabolism or exposure to xenobiotics.  Excessive levels of ROS are associated with oxidative damage to lipids, proteins and DNA.   Because oxidation of DNA occurs readily at the guanosine bases, measurement of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) serves as an excellent biomarker of ongoing oxidative damage or stress in the body.  The DNA Oxidative Damage Assay from Doctor's Data offers a non-invasive, cost-effective assessment of urinary 8-OHdG.

When urinary 8-OHdG levels are elevated, it is important to identify the sources of oxidative stress while also assessing the primary intracellular antioxidant glutathione. Even moderately elevated levels of 8-OHdG have been associated with inadequate intake of carotenoids, antioxidant-rich foods and supplemental antioxidants. Taking steps to reduce oxidative stress is valuable in optimizing health and longevity.

 
 

 
 

DNA Oxidative Damage Profile in Summary
 

  • Quantitative assessment of ongoing oxidative damage
  • Biomarker of cellular oxidative stress
  • Monitors the effects of detoxification and antioxidant therapies
  • Simple first morning void (FMV) urine collection
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Oxidative stress and ROS-induced elevations of urinary 8-OHdG have been associated with numerous pathological processes including:
 

              

                   

Alzheimer's Disease
Atopic Dermatitis
Chronic Hepatitis
Cystic Fibrosis
Diabetic Nephropathy
Diabetic Retinopathy
Huntington's Disease

                   

Hyperglycemia
Inflammatory Bowel Disease
Metabolic Syndrome
Oxidative Stress
Pancreatitis
Parkinson's Disease
Rheumatoid Arthritis

 

 

 

 

 
 
Environmental factors associated with elevated urinary 8-OHdG include exposure to:
 

                   

asbestos
benzene
chromium fumes
cigarette smoke
diesel exhaust
indoor radon             

                    

manganese fumes
styrene
touene
toxic metals
vanadium fumes
zylene

 

 

 

 

 
 
How does DNA oxidative damage (urinary 8-OHdG) relate to SNPs?
 

Methionine metabolism (methylation) and detoxification pathways (transsulfuration) can be compromised by the expression of certain SNPs (MTHFR, MTR, CBS, SHMT, etc.). These SNPs may affect the body's ability to synthesize glutathione, the primary antioxidant in the body. Furthermore, many genes in the body are turned on and off in part by DNA methylation.  In each case, SNP-associated changes may result in excessive oxidative stress and ultimately damage to mitochondrial and nuclear DNA.  Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) is an excellent biomarker for oxidative stress and the DNA damage it causes.

 

 
 
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Want to see the latest research on this topic?

 
Nakazato T, Ito C, Aisa Y.   Oxidative Stress Is Associated with Poor Prognosis in Patients with Malignant Lymphoma .  Blood 2014 Dec 6;124 (21)
 
Prasad SB, Vidyullatha P, Vani GT, Devi RP, Rani UP, Reddy PP, Prasad HM. Association of gene polymorphism in detoxification enzymes and urinary 8-OHdG levels in traffic policemen exposed to vehicular exhaust. Inhal Toxicol. 2013 Jan;25(1):1-8.
 
Kikuchi H, Nanri A, Hori A, Sato M, Kawai K, Kasai H, Mizoue T. Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine. Nutr Metab (Lond). 2013 Oct 2;10(1):59.

 

 
 

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Why choose Doctor's Data, Inc.?

 
Doctor's Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced CLIA-licensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes.  Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, cardiovascular risk, liver and metabolic abnormalities, and more.