Doctor's Data offers scores of distinct tests across key categories:
Allergy & Immunology
Bloodspot
Cardiovascular
Clinical Microbiology

      
Endocrinology
Environmental Exposure/Detoxification
Nutritional
Toxic & Essential Elements

      
 

Gauging the Body's Ability to Eliminate Toxins

 
Every day we come in contact with a seemingly unlimited number of xenobiotic substances. These exposures may occur in our homes, the workplace, and our food supply and with every breath we take. Each day we are prone to the uptake of small amounts of these substances and our bodies may not have the capacity to process and excrete them all safely. Xenobiotics that are not metabolized are stored in fat cells throughout the body where they continue to accumulate. As they accrue they can potentially alter our metabolism, cause enzymatic dysfunction and nutritional deficiencies, create hormonal imbalances, damage brain chemistry and even cause cancer. It is important to assess environmental exposure, identify the source and support the innate detoxification process.

    

 Doctor's Data offers a spectrum of tests designed to evaluate the exposure to environmental toxins, and assess the body's capacity for endogenous detoxification.
 
 
Hepatic Detox
 
The urine Hepatic Detox profile is used to detect significant toxicant exposure and the activity of the primary pathway of Phase II detoxification. Hepatic exposure to a vast array of toxicants causes concomitant up-regulation of both cytochrome P-450 isozymes and the glucuronic acid pathway. In humans this pathway ends with D-glucaric acid; therefore elevated levels of D-glucaric acid in urine indirectly indicate up-regulation of Phase I detoxification as a result of exposure to xenobiotics.
  
   
 

Mercapturic acids are final conjugated products of Phase II detoxification and include sub functional xenobiotics that have been conjugated with glutathione and/or L-cysteine prior to excretion. Urinary levels of Mercapturic acids are indicative of the quantitative degree of activity or capabilities of Phase II detoxification. Subordinate levels of Mercapturic acids are consistent with inadequate levels of glutathione and/or cysteine or insufficient glutathione-S-transferase (GST) activity. The clinical utility of the Hepatic Detox profile is that it portrays the balance or imbalance of Phase I and Phase II detoxification processes. 
  

 


(Click image for more details about this test.)
 
DNA Oxidative Damage

   

Compounding the effects of environmental toxicants, excessive production of reactive oxygen species can lead to oxidative damage in the body. Oxidation of DNA occurs readily at the guanosine bases, thus the DNA Oxidative Damage profile measures 8-hydroxy-2'- Deoxyguanosine (8-OHdG) in urine and affords a quantitative assessment of ongoing oxidative damage or stress in the body. Elevated 8-OHdG has been associated with endothelial dysfunction in prediabetics. Assessing levels of 8-OHdG is also helpful for monitoring the efficacy of detoxification and antioxidant therapies.
  

 
(Click image for more details about this test.)
 
RBC Glutathione
 
Glutathione (GSH) is the most abundant and important intracellular antioxidant that is produced in the body. It is involved in countless biological processes including detoxification of xenobiotics, elimination of reactive oxygen species, regulating immune function and the overall health of cells. Low levels of GSH have been reported in cardiovascular disease, cancer, autism and neurodegenerative diseases such as Alzheimer's and Parkinson's.
 

Reduced GSH (rGSH) is the active form of the tripeptide and the ratio of rGSH to oxidized GSH (GSSH) is normally about 9:1. Research indicates that aberrant ratios of rGSH:GSSH are equally correlated with abnormally low levels of total cellular GSH. Therefore, it is clinically meaningful to assess the level of total erythrocyte GSH as an indicator of GSH status and metabolism.

 
Plasma Methylation
 
Methylation is a biochemical process that is involved in virtually every function within the body. Normal methionine metabolism is critical for methylation of DNA/RNA, phospholipids, protein, and metabolism of neurotransmitters and toxicants. Many factors, genetic and epigenetic, can disrupt methionine metabolism (methylation and transsulfuration). Therefore the Plasma Methylation profile was developed at Doctor's Data to provide a functional assessment of the net phenotypic effects of SNPs, nutrient insufficiencies and toxicants on methionine metabolism, including the key methylation index ratio of SAM to SAH (SAM:SAH).
 

 
(Click image for more details about this test.)

 
The results of a Plasma Methylation test can be used to determine appropriate nutritional support or intervention to normalize methionine metabolism and potentially circumvent antagonistic consequences associated with impaired methylation.
   
 
 
Follow the links below to view other suggested Doctor's Data profiles:
 
  
Do you have questions about this or any of our other tests? Click the button below to complete our contact request form and your territory representative will reach out to you shortly.
 
 
 

 
Want to see the latest research on this topic?
   

Guo Y, Weck J, Sundaram R, Goldstone A, Louis GB, Kannan K. Urinary Concentrations of Phthalates in Couples Planning Pregnancy and Its Association with 8-Hydroxy-2'-deoxyguanosine, a Biomarker of Oxidative Stress: Longitudinal Investigation of Fertility and the Environment Study. Environ. Sci. Technol. 2014, 48, 9804-9811

James, SJ et al. Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism. J Autism Dev Disord. 2012 Mar; 42(3): 367–377.

Faber S, Zinn GM, Boggess A, Fahrenholz T, Kern II JC and Kingston HM. A cleanroom sleeping environment's impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders. BMC Complementary and Alternative Medicine (2015) 15:71

Maschirow L, Khalaf K, Al-Aubaidy HA, Jelinek HF. Oxidative stress and inflammation associated with decreased fibrinolysis as an early marker for peripheral vascular disease stratification: A clinical study. Clin Biochem 2015.
 

 
 
Why choose Doctor's Data Inc.?
                                
Doctor's Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced CLIA-licensed clinical laboratory since 1972.

A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes.  Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, cardiovascular risk, liver and metabolic abnormalities, and more.