Collection Type

NAD Profile; whole blood

Collection kits will be available to order beginning May 1, 2026

NADs: Metabolic Powerhouses

In the body, B3 vitamins manifest as NADs (nicotinamide adenine dinucleotides). NADs are crucial molecules central to diverse cellular processes, notably energy metabolism. Comprised of four types of NAD, they play a vital role in redox reactions and a wide array of other cellular functions. Additionally, NADs are key players in regulatory pathways, influencing processes such as DNA repair and cell survival. Their significance in cellular activities makes them targets for research and interventions related to health, longevity, and disease.

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Useful for:

• Unexplained fatigue or low stress tolerance
• Exercise intolerance or suspected myopathy
• Possible mitochondrial dysfunction
• Neurodegenerative conditions
• Post-viral or chronic fatigue syndromes
• Diabetes, insulin resistance
• Rare congenital NAD+ synthesis defects
• Dyslipidemia with impaired fatty acid oxidation patterns
• Low B2/B3/B6 or tryptophan metabolism abnormalities
• Malabsorption or chronic GI inflammation affecting B vitamin status
• Impaired detoxification involving NAD dependent dehydrogenases
• Biological aging, sarcopenia, frailty
• TBI or post concussive syndrome
• Peripheral neuropathy (diabetic, toxicant related)
• Chemotherapy related mitochondrial stress
• Toxicant exposure (metals, xenobiotics, mold)
• Chronic inflammation with high oxidative stress burden
• MASLD / NASH

Turnaround Time

5 to 7 days

Note: Turnaround times on results are an estimate and are not guaranteed. The lab may need additional time due to holidays, confirmation/repeat testing, etc. You can contact us to discuss when your results should be ready.

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.

List price applies when filing with insurance or Medicare, or when billing a patient directly. Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

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Detailed Information

Why Measure NADs?

Intensive NAD supplementation and consequent significantly elevated NAD levels are associated with an increased risk of mortality, as they may enhance mechanisms that contribute to heart attacks, strokes and cancer. Furthermore, extremely high NAD levels are correlated with heightened insulin resistance, leading to various metabolic disorders (e.g., type 2 diabetes). NAD levels fluctuate in response to stress, as the body rapidly consumes NAD+ to adapt its physiological functions. This is why depleted NAD+ levels are associated with various conditions, including Alzheimer’s, Parkinson’s, diabetes, chronic fatigue syndrome, obesity, and inflammation. In some cases, low NAD+ levels can also impair the body’s ability to metabolize drugs or respond effectively to treatments due to insufficient cellular energy. To address declined NAD levels, supplementation may be a consideration. Responses to NAD therapy vary among individuals. To mitigate potential complications, it is important to establish patients’ NAD status and continuously monitor their levels throughout the entire therapy.

Importance of the NAD+ and NADH ratio

For the clearest assessment of mitochondrial and metabolic health, it is essential to measure both the reduced and oxidized forms of NAD: NAD+ and NADH. Their ratio indicates whether the mitochondria are functioning properly. Measuring NAD+ alone provides valuable insights, but only tells half the story.