Doctor's Data Inc

Calprotectin Stool

Calprotectin is a reliable noninvasive marker for differentiating gastrointestinal inflammation associated with Inflammatory Bowel Disease (IBD) from inflammation that may be associated with Irritable Bowel Syndrome (IBS). Such differentiation is very important because IBD can be life threatening. Monitoring the levels of fecal calprotectin can play an essential role in determining the effectiveness of clinical interventions, and is a good predictor of IBD remission and relapse. Calprotectin provides clinicians with a valuable tool, not only for differentiating IBD from IBS, but also allowing them to monitor and predict treatment outcomes and enabling better management of IBD flare ups.


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Turnaround Time

4 to 6 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.

Analyte CPT ABN Required
Calprotectin; stool 83993 Yes

List price applies when filing with insurance or Medicare, or when billing a patient directly.

Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

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Detailed Information

Calprotectin is a calcium-binding protein produced by neutrophils and monocytes, and it may be involved in inflammatory signaling. Elevated Calprotectin and fecal Lactoferrin levels indicate the presence of neutrophils and inflammation in the gastrointestinal (GI) mucosa. Calprotectin and Lactoferrin differentiate between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). IBD includes autoimmune conditions such as Crohn’s disease and ulcerative colitis (UC); these conditions may become life-threatening and require lifelong treatment.

Multiple studies have shown fecal Calprotectin and Lactoferrin to be equivalent with respect to clinical sensitivity and specificity. Studies suggest that Calprotectin may correlate more closely with histological (cell microscopy) findings. Lactoferrin may correlate better to macroscopic (endoscopy) findings, and may be the better indicator of impending relapse, elevating 2-3 weeks prior to clinical symptoms.

Chronic inflammation of the gastrointestinal mucosa contributes to symptoms of IBD. Chronic stress is known to contribute to symptom flare-ups and increased inflammation. Liver disease or the use of aspirin or nonsteroidal anti-inflammatory (NSAID) medications may elevate Calprotectin levels. Fecal Calprotectin levels may also be increased in newborns.

Clinical Microbiology

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