Doctor's Data Inc

Metabolomic Profile

The Metabolomic Profile provides assessment of the likelihood of Metabolic syndrome in at-risk patients.  The Metabolomic Profile evaluates seven biomarkers that may reflect a patient’s risk of developing Metabolic syndrome, which is identified by a cluster of cardiometabolic risk factors, with insulin resistance and adiposity as its central features. Identification of individuals with metabolic syndrome is important due to its association with an increased risk of and type 2 diabetes mellitus, renal damage and coronary heart disease. Early detection of risk for Metabolic Syndrome is very important because associated symptoms may not be evident until it is well advanced.

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Turnaround Time

5 to 7 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.


Analyte CPT ABN Required
Adiponectin; serum 83520 Yes
Body Mass Index (BMI) No
C-Reactive Protein; serum 86141 No
Creatinine; serum with eGFR 82565 No
Cystatin C; serum 82610 No
Glucose; serum 82947 No
Glycomark (1,5-AG); serum 84378 Yes
Insulin; serum 83525 No
Leptin : Adiponectin ratio No
Leptin; serum 83520 Yes

List price applies when filing with insurance or Medicare, or when billing a patient directly.

Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

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Detailed Information

Doctor’s Data offers the Metabolomic Profile due to increasing awareness of the need to detect Metabolic syndrome before it progresses to adult-onset diabetes and related health consequences. The profile is designed to assess the likelihood of Metabolic syndrome (MetS) in at-risk patients.  Metabolic syndrome may occur at all stages in life.  The number of people with MetS has increased over the last two decades. It is estimated that greater than 18% of US adolescents, 30% of young – midlife adults, and 40% of senior adults (> 70 y.o.) have MetS.  
The incidense of MetS is increasing at an alarming rate. Controllable epigenetic factors clearly have a causal role.  Contributing factors may include obesity, insulin resistance, polycystic ovary disease, hormone imbalance or a sedentary, unhealthy (smoking, etc.) lifestyle.    “Over nutrition” and poor dietary choices (highly processed, high fat, high salt, high sugar “empty-calorie” foods), combined with sedentary habits interact with our genetic programming: we store extra calories as fat.  Fat cells (adipocytes) produce hormones (adipokines) that interact with the hypothalamus and or immune system and may have pro-inflammatory or anti-inflammatory effects.  Altered adipokine levels have been observed in MetS.  Insulin (fasting) resistance is a hallmark feature of MetS. The biomarkers that constitute the Metabolomic Profile include:

Glycomark (1,5-anhydroglucitol) –indicates poor control of blood glucose spikes; specifically frequent hyperglycemic events over the past two weeks (not evidentfrom HbA1c). Postprandial hyperglycemia is associated with Cardiovascular disease and reduction of hyperglycemic events appear to decrease macro- and microvascular complications in diabetic patients. Low 1,5-AG is also associated with renal damage. Hemoglobin A1c (HbA1c) – estimates the average blood glucose concentration for the life of the red blood cell (120 days)
Insulin – levels of insulin elevate early in type II diabetes, and then decrease as pancreatic beta cells lose function.
Leptin – is a hormone produced by adipocytes to provide a satiety signal to the hypothalamus. Elevated circulating levels of leptin are associated with adipose tissue abundance and a leptin resistance. High levels of this adipokine  have pro-inflammatory effects, and leptin accelerates arterial foam cell formation. Adiponectin – improves insulin sensitivity and stimulates glucose uptake and hepatic fatty acid oxidation. Very low levels of this anti-inflammatory adipokine may increase the risk forCVD and some cancers.
Leptin to Adiponectin ratio- the ratio of leptin to adiponectin appears to be a sensitive indicator for a variety of adverse health conditions.
Cystatin C, Creatinine and eGFR – renal damage is a common consequence of MetS and hyperglycemia. Cystatin C is considered to be a better indicator of GFR than serum creatinine or calculated GFR (eGFR).

Patients that may especially benefit from the Metabolomic Profile include those with:
  • Excess abdominal adiposity or body mass index (BMI) >30
  • High triglycerides or need for cholesterol medication
  • Low HDL cholesterol or need for cholesterol medication
  • Hypertension or need for hypertension medication
  • Fasting Glucose > 100 mg/dL
  • Family or personal history of cardiovascular disease, high cholesterol or type II diabetes
  • Personal history of chronic inflammatory disease
Except for obesity, the risk factors for MetS, and the chronic diseases that may develop from it, may present no symptoms until well advanced.  The greatest window of opportunity to prevent the development of atherosclerosis, type II diabetes, renal damage or heart failure may occur during the early, symptom-free stages of MetS.  Early detection and intervention through diet and lifestyle changes may prevent the development of symptoms or disease complications. The Metabolomic Profile facilitates clinicians in the early detection of Metabolic syndrome.

Cardiometabolic

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