Doctor's Data Inc

Neuro-Biogenic Amines, Comprehensive; Urine

Urinary neuro-biogenic amines provide an overall assessment of a patient's ability to synthesize and metabolize neurotransmitters, both in the periphery and, for some enzymes, behind the blood brain barrier as well.  Alterations in urinary neurotransmitter status may be associated with a variety of conditions including metabolic disorders, mood/behavioral disorders, and in rare occasions the presence of certain tumors. Associations between urinary neurotransmitter levels and health conditions have been documented in scientific literature and may provide valuable insights as part of a comprehensive health assessment.


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Turnaround Time

5 to 7 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.


Analyte CPT ABN Required
3,4-Dihydroxyphenylacetic acid (DOPAC); urine 82542 No
3-Methoxytyramine (3-MT); urine 82542 No
5-Hydroxyindolacetic acid (5-HIAA); urine 83497 No
Creatinine urine 82570 No
Dopamine, free; urine 82384 No
Epinephrine, free; urine 82384 No
Gamma-aminobutyrate; urine 82139 No
Glutamate; urine 82139 No
Glycine, urine 82136 No
Histamine; urine 83088 No
Metanephrine; urine 83835 No
Norepinephrine : Epinephrine ratio No
Norepinephrine, free; urine 82384 No
Normetanephrine; urine 83835 No
Phenethylamine (PEA); urine 82136 No
Serotonin; urine 84260 No
Taurine, urine 82139 No
Tryptamine; urine 82139 No
Tyramine; urine 82139 No
Tyrosine, urine 82139 No

List price applies when filing with insurance or Medicare, or when billing a patient directly.

Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

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This test is useful for

  • Functional testing for COMT and MAOA
  • Identifying neurological imbalances
  • Measuring response to therapy
  • Risk assessment

Detailed Information

Analysis of urinary neuro-biogenic amines (neurotransmitters), and their metabolites, provides a non-invasive assessment of neurotransmitter metabolism. Neurotransmitter testing may provide therapeutic opportunities that improve clinical success and patient health outcomes. A review of the current scientific literature demonstrates how urinary neuro-biogenic amine testing may be used in clinical practice:

  • Functional testing - Neuro-biogenic amine metabolism may be mediated by a variety of enzymes, including catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO).  Patterns of neurotransmitters and their metabolites may provide functional information about these two important enzymes.
  • Identify imbalances - research indicates that urinary neuro-biogenic amine measurements may correlate with neurological conditions such as depression and PTSD.
  • Response to therapy - certain neuro-biogenic amines, such as serotonin, may be altered by the addition of neurotransmitter precursors such as 5-hydroxytryptophan (5-HTP).  These changes may be apparent in the urine.
  • Risk assessment - Changes in urinary serotonin, dopamine, and glutamate levels have been suggested as biomarkers for neurobehavioral toxicology (symptoms from chemical or toxicant element environmental exposures)
  • Neurotransmitters, or "biogenic amines" are secreted from pre-synaptic neurons into the synapse between nerve cells to stimulate receptors on post-synaptic neurons. The neurotransmitters are all produced from essential aromatic amino acids.  Neurotransmitter metabolism may be mediated by a variety of enzymes expressed differently throughout the body.  Circulating levels of neurotransmitters and metabolites may have distinctive sources.  Urinary levels of neuro-biogenic amines primarily reflect the activity of the peripheral and GIT enteric nervous systems.  Up to 20% of urinary neurotransmitter metabolites are estimated to originate in the CNS.   A lack of nutritional cofactors (vitamins, minerals) required for normal enzyme function may decrease enzyme function and neurotransmitter levels.  Neurotransmitter receptors and metabolic enzymes may be subject to mutations and single nucleotide polymorphisms (SNPs) that may affect receptor or enzyme function.  Normal neurotransmitter receptor function is also necessary for normal neurotransmitter activity.  Neurotransmitter levels may be influenced by diet, lifestyle and other health conditions such as: high sodium intake, age, gender, body mass index, kidney function, environmental exposures, infection and tobacco use. Urinary neuro-biogenic amines provide an overall assessment of a patient's ability to synthesize and metabolize neurotransmitters, which must occur in both the peripheral nervous system and behind the blood brain barrier (BBB).  Alterations in urinary neurotransmitter status may result from a variety of conditions including metabolic disorders, mood/behavioral disorders, environmental exposures or (rarely) the presence of certain tumors.  Evaluation of neurotransmitters may provide increased clarity about a patient's health and functional status.   Urinary neuro-biogenic amines are a non-invasive way to assess the synthesis and metabolism of neurotransmitter molecules essential for normal function.  Information gained through neurotransmitter testing may provide therapeutic opportunities that improve clinical success and patient health outcomes.  Associations between urinary neurotransmitter levels and health conditions have been documented in scientific literature and may provide valuable insight as part of a comprehensive health assessment.

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