Doctor's Data Inc

Oxidized LDL

Plasma levels of Ox-LDL are a sensitive biomarker of atherosclerosis. Elevated Ox-LDL is associated with accelerated atherogenesis, CAD, acute myocardial infarction, and stable and unstable angina. High Ox-LDL has also been associated with metabolic syndrome, impaired glucose tolerance and insulin resistance, and untreated overt hypothyroidism.
Learn more »

Turnaround Time

5 to 7 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.


Analyte CPT ABN Required
Oxidized LDL; serum 83520 No

List price applies when filing with insurance or Medicare, or when billing a patient directly.

Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

Sign in at the top of any page to view pricing and order tests. Or click here to create an account. You may also contact us for assistance placing an order.

This test is useful for

  • Coronary Artery Disease
  • Heart Attack
  • Metabolic Syndrome
  • Type 2 Diabetes
  • Oxidative Stress

Detailed Information

Oxidized low density lipoproteins are directly involved in the initiation and progression of atherosclerotic lesions in coronary arteries that can result in atherosclerotic coronary artery disease (CAD). This test measures plasma levels of oxidized low density lipoproteins (Ox-LDL) using a highly sensitive and specific immunoassay. Plasma levels of Ox-LDL are a sensitive biomarker of atherosclerosis. Elevated levels of Ox-LDL are associated with accelerated atherogenesis, CAD, acute myocardial infarction, and stable and unstable angina. It's important to note that total cholesterol levels are not necessarily higher than normal in patients with unstable CAD. Elevated Ox-LDL has also been associated with metabolic syndrome, impaired glucose tolerance and insulin resistance, and untreated overt hypothyroidism. Low density lipoproteins (LDL), the major carrier of circulating cholesterol, are very susceptible to oxidation of the constituent apolipoprotein B-100 moiety by prooxidants such as metal ions, reactive oxygen radicals, oxidized macrophages, lipoxygenase and peroxynitrite. When the LDL protein is oxidized it becomes antigenic and the Ox-LDL are taken up excessively by the unregulated "scavenger" or Ox-LDL receptors on monocyte-derived macrophages. Unoxidized native LDL are not involved in the unregulated uptake process and Ox-LDL is present in macrophages in atherosclerotic lesions but not in normal arteries. Once macrophages breach the damaged arterial endothelial barrier, the excessive uptake of lipids form Ox-LDL contributes to their entrapment in the sub-endothelial space. The trapped lipid-laden "foam" cells elicit biosynthesis and release of factors by endothelial cells that are pro-inflammatory and chemotactic for other monocytes, perpetuating the atherosclerotic process with injury to the arteries. Injury to the sub-endothelial vessel walls results in decreased production of nitric oxide and elasticity of the arteries and the damaged lipid-laden arteries eventually narrow, restricting the flow of blood. Increased antioxidant protection and amelioration of oxidative stress would be expected to decrease levels of atherogenic Ox-LDL. These test results should be interpreted in context with the constellation and severity of symptoms and findings, as well as family history. Direct testing for CAD may be warranted if the level of Ox-LDL is undesirable.

Cardiometabolic

Find out more