sex-hormones-profile-urine sex-hormones-profile-urine
Sex Hormones Profile; urine Sex Hormones Profile; urine

Sex Hormones Profile; urine

The Sex Hormones Profile provides a broad overview of sex steroid hormones, their metabolites, and the efficiency of the enzymes that metabolize these hormones. This non-invasive test requires only 4 or 5 separate urine collections. Because the breakdown of hormones relies so heavily on processes within the liver, this test can also elucidate areas of interest as it pertains to conjugation of each metabolite. Additionally, testing urinary hormone metabolites can contribute to further understanding of endogenous hormone secretion, supplemental hormone utilization, enzyme activity, oxidative stress, and insight into whether your body is safely metabolizing hormones.

This profile is a consideration for patients with concerns that are particular to sex hormones and/or monitoring for harmful metabolites due to the influence of HRT/BHRT. Patient FAQs and Best Practices for HuMap

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Useful for:

  • Metabolic syndrome
  • Thyroid pathologies
  • Inflammation
  • Fatigue/insomnia
  • Libido
  • Mood or cognitive concerns
  • Family history of hormone-driven cancers
  • HRT/BHRT utilization
  • Weight gain

Turnaround Time

5 to 7 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.


List price applies when filing with insurance or Medicare, or when billing a patient directly. Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

Sign in at the top of any page to view pricing and order tests. Or click here to create an account. You may also contact us for assistance placing an order.

Detailed Information

The Sex Hormones Profile reports not only important markers and metabolites, but it also calculates the relationship of catechol estrogens (2OHE1, 4OHE1, and 16OHE1) representative of phase 1 detox as well as phase 2 activity of the COMT enzyme via methoxy estrogen ratios. Understanding how catechol estrogens break down as well as the rate of methylation, which renders potentially harmful metabolites inactive, can help mitigate risk and determine individualized treatment.

Determining the preference for 5-alpha vs. 5-beta is desirable for optimal health. 5α-reductase converts testosterone into the metabolite 5α-DHT which is three times more potent than testosterone. Symptoms associated with higher androgen levels (thinning hair, acne, etc.) are often seen when levels of 5α-reductase and its corresponding metabolites are elevated. Additionally, the activity of aromatase (CYP19) is an integral part of the health of both men and women. Aromatase is more active in peripheral tissues increasing estrogens in males as well as the main source of estrogens in the postmenopausal female. Determining the activity of aromatase can assist with understanding the root cause of lower testosterone as well as estrogen dominance.

Progesterone is found in the urine in very small quantities due to its molecular structure making it difficult to obtain without sensitive LCMS testing methodologies. The Sex Hormones Profile measures the metabolites of progesterone, (5α-pregnanediol and 5β-pregnanediol), and also progesterone itself. This level will be of particular interest to practitioners prescribing oral progesterone as they may now track the metabolism of progesterone into its metabolite allopregnanolone, known to have GABA like effects for sleep and relief of anxiety.