Doctor's Data Inc

Zonulin; stool

The level of the zonulin antigen in stool may provide a noninvasive indication of intestinal permeability (“leaky gut”). Research to date has identified zonulin as the only physiologically reversible regulator of permeability of the GI endothelial cell barrier. Numerous studies have shown that a chronically high release of zonulin from the GI epithelial cells is associated with Celiac disease, non-celiac gluten sensitivity (NCGS), Diabetes, chronic hyperglycemia, cigarette smoking and other GI and systemic autoimmune and pro-inflammatory conditions.

 In a healthy GI tract, the tight junction protein complexes between endothelial cells prevent unregulated influx of luminal contents. However, specific triggers, such as gliadin for people with celiac disease or NCGS, can lead to high levels of zonulin in the GI tract. This can induce the breakdown of the tight junctions, leading to excessive paracellular influx of pro-inflammatory and highly antigenic macromolecules.

 As a result, an elevated level of the zonulin antigen in stool is a clinically useful biomarker of intestinal permeability. What's more, it can be valuable for monitoring therapeutic interventions as well. Fecal zonulin can be ordered as a stand-alone test or as an add-on to a Comprehensive Stool Analysis.

Turnaround Time

4 to 6 days

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.

Analyte CPT ABN Required
Zonulin; stool 83520 Yes

List price applies when filing with insurance or Medicare, or when billing a patient directly.

Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

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Gastrointestinal Health

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