Doctor's Data Inc

Zonulin Family Protein; stool

Elevated fecal levels of a zonulin family protein (ZFP) have been associated with metabolic syndrome and obesity; conditions that have been linked to increased intestinal permeability ("leaky gut"). Elevated serum levels of the ZFP antigen have been correlated with results from the established lactulose mannitol test. Definitive research has yet to be published regarding a correlation between fecal ZFP levels and the results of the lactulose mannitol test.

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Turnaround Time

4 to 6 days

Analytes Tested

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Analyte CPT ABN Required
Zonulin Family Protein; stool 83520 Yes

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Detailed Information

A yet to be conclusively identified zonulin family protein (ZFP), possibly properdin, modulates the reversible breakdown of tight junction protein complexes (TJP) between gastrointestinal epithelial cells. Loss of integrity of the epithelial barrier permits paracellular influx of highly antigenic and pro-inflammatory polypeptides and other macromolecules from the lumen of the intestine. High serum levels of ZFP (antigen) are highly correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability.  Elevated fecal levels of ZFP have been associated with metabolic syndrome, obesity, and apparently healthy cigarette smokers. Elevated serum levels of zonulin have been correlated with results from the established lactulose mannitol test, but to date no such correlation has been reported with fecal zonulin. Excessive intake of simple sugars, sodium, emulsifiers, microbial transglutaminase ("meat glue") and nano-particles may also be triggers for increased fecal ZFP and intestinal permeability. Clinically the key is to first eliminate exposure to the trigger(s) of excessive ZFP. Possible interventions to restore the gastrointestinal mucosal barrier include dietary changes, treatment of dysbiosis, digestive supports and anti-inflammatory supplements; specifically quercetin, vitamin C, curcumin, gamma-linoleic acid, omega-3 fatty acids (EPA, DHA), and aloe vera. other nutrients such as zonc, beta-carotene, pantothenic acid, and L-glutamine may provide some support for rejuvenation of the mucosal barrier. The use of some probiotics has been show to reduce serum and fecal zonulin levels, and unulin (about 10 grams per day) lowered serum zonulin after just five days in healthy young subjects. Consider a comprehensive Stool Analysis to further investigate porential causes of increased intestinal permeability.

Gastrointestinal Health

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